down-regulation - A reduction in the number of receptors for a control substance, e.g., a hormone, local hormone, neurotransmitter, or a drug, in response to a prolonged excess of the control substance; this is an internal adjustment which usually helps restore homeostasis in a disease state.
up-regulation - An increase in the number of receptors for a control substance, e.g., a hormone, local hormone, neurotransmitter, or a drug, in response to a prolonged decrease of the control substance; this is an internal adjustment which usually helps restore homeostasis in a disease state.
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